USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critical role in the stability of receptor tyrosine kinases. USP8 has been demonstrated to regulate the stability of Nrdp1, a E3 ubiquitin ligase.
|Molecular weight||138 kDa (With tags)|
|Storage||Store at -80°C, avoiding repeated freeze-thaw cycles.|
|Alternative Names||Deubiquitinating enzyme 8, hUBPy, HumORF8, KIAA0055, MGC129718, Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin-specific processing protease 8, Ubiquitin thioesterase 8, UBPY|
|Expression Host||E. coli|
|Suggested Substrate||Ub-CHOP Reporter (Cat. # PR1001)|