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LifeSensors

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Ubiquitin and Neuroscience

Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein aggregates, which induce specific pathological conditions. The ubiquitin proteasome system and autophagy play key roles in the regulation of protein homeostasis in neurons. Accordingly, dysfunction of the enzymes in these pathways are critical to understanding and ultimately treating a variety of neurodegenerative disorders.



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USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in..
$295.00

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USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in..
$325.00

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USP14 is a ubiquitin specific protease that associates with the proteasome. This association with th..
$125.00

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K6-linked di-ubiquitin (Ub2) is a diubiquitin linked by a native isopeptide bond between the C-ter..
$225.00

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K6-linked di-ubiquitin (Ub2) is a diubiquitin linked by a native isopeptide bond between the C-ter..
$65.00

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UbcH1 (also known as E2-25K) is an E2 conjugation enzyme that is involved in the ubiquitylation of t..
$41.25

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UbcH1 (also known as E2-25K) is an E2 conjugation enzyme that is involved in the ubiquitylation of t..
$165.00

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UbcH1 (also known as E2-25K) is an E2 conjugation enzyme that is involved in the ubiquitylation of t..
$41.25

Available Options

UbcH1 (also known as E2-25K) is an E2 conjugation enzyme that is involved in the ubiquitylation of t..
$165.00

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E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugatio..
$180.00

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ITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting var..
$195.00

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Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes..
$395.00

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Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes..
$625.00

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UCHL1 (PGP9.5) is a 25 kDa protein; it is highly specific to neurons and to cells of the diffuse neu..
$125.00

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USP30 is a deubiquitinase involved in the regulation of mitophagy.  It is attached to the out..
$170.00

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BackgroundThe diubiquitin substrates represent a new class of continuous assay substrates for the ..
$325.00

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K6-linked tetra-ubiquitin is a useful substrate for identifying and characterizing deubiquitinating..
$325.00

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PTEN-induced putative kinase protein 1 (Serine/Threonine kinase PINK1) is an important protein tha..
$325.00
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