Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.
Functionalized cereblon ligand for PROTACs
CAS Number 1061605-21-7
Physical State: Lyophilized off white solid
Quantity: 5mg; 10mg; 25mg
Solubility: 30 mg/mL in DMSO
Storage: Store at room temperature.
1. Lohbeck and Miller (2016) Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: