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PC1006 Thalidomide 5g

  • Product Code: PC1006 Thalidomide 5g
  • Availability: Contact us for lead time

Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.


Binds cereblon, inhibiting ubiquitin ligase activity; alsoTNF-a synthesis inhibitor

Product Information

Purity:                            >98% 

MW:                                   258.24

Formula:                            C13H10N2O4

CAS Number:                    50-35-1

Physical State:           Lyophilized white solid

Quantity:                           1g; 5g

Solubility:                           6 mg/mL in DMSO

Storage:                           2-8°C



1.    Boireau et al (1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett. 234 123 PMID: 9364513

2.    Kanbayashi et al (1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881 PMID: 8905685

3.    Makonkawkeyoon et al (1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 90 5974 PMID: 8327469

4.    Zhang et al (2008) Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 27 60 PMID: 18983651

5.    Sampaio et al (1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699 PMID: 1997652

6.    Merck Index 12 9390

7.    Ito et al (2010) Identification of a primary target of thalidomide teratogenicity. Science 327 1345 PMID: 20223979

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