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PC1005 Pomalidomide 1g

$45.00
  • Product Code: PC1005 Pomalidomide 1g
  • Availability: In Stock
Tags: PROTAC

Potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic.


Application


Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic


Product Information


Purity:                                         >95% 

MW:                                                273.24

Formula:                                C13H11N3O4

CAS Number:                                19171-19-8

Physical State:                        Lyophilized pale-yellow to yellow-brown solid

Quantity:                                1g; 5g

Solubility:                                25 mg/mL in DMSO

Storage:                                        Room Temperature


Documents



References


1.    Lohbeck & Miller (2016) Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673

2.    Nanthakumar et al (2015) Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat.Rev.Drug.Discov. 14 693 PMID: 26338155

3.    Lai et al (2016) Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew.Chem.Int.Ed.Engl.55 807 PMID: 26593377

4.    Winter et al (2015) Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 3481376 PMID: 25999370




Thumb File information
Pomalidomide D atasheet.pdf 169.62KB 0

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