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LifeSensors

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PROTAC

PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules capable of degrading disease-causing proteins by inducing selective intracellular proteolysis. These small molecules simultaneously engage a target protein and an E3-ubiquitin ligase, thus causing selective ubiquitination and degradation of the target protein by the proteasome.



PROTAC Compounds


Tools for PROTAC R&D


Tools for Measuring Target Ubiquitylation


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Cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated to a von..
$285.00

Available Options

Cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated..
$1,295.00

Available Options

dBET1 is a potent and selective BRD4 protein degrader. The molecule, dubbed “degronimid”, is harness..
$235.00

Available Options

dBET1 is a potent and selective BRD4 protein degrader. The molecule, dubbed “degronimid”, is harness..
$495.00

Available Options

dBET1 is a potent and selective BRD4 protein degrader. The molecule, dubbed “degronimid”, is harne..
$135.00

Available Options

High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between ..
$195.00

Available Options

High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between ..
$475.00

Available Options

High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between..
$105.00

Available Options

Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination a..
$35.00

Available Options

Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and..
$125.00

Available Options

Potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thali..
$45.00

Available Options

Potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidom..
$175.00

Available Options

Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, in..
$35.00

Available Options

Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inh..
$95.00

Available Options

Small molecule-induced protein degradation is an attractive strategy for the development of chemical..
$55.00

Available Options

Small molecule-induced protein degradation is an attractive strategy for the development of chemical..
$95.00

Available Options

Small molecule-induced protein degradation is an attractive strategy for the development of chemica..
$35.00

Available Options

Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs that ..
$75.00

Available Options

Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs that ..
$165.00

Available Options

Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs tha..
$45.00
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