putative kinase protein 1 (Serine/Threonine kinase PINK1) is an important
protein that saves the dysfunction of mitochondria upon application of cellular
stress. When the mitochondria is depolarized, PINK stabilizes and gets
accumulated. When E3 Ubiquitin Ligase Parkin (PARK2) is brought to the damaged
mitochondria, it is activated by PINK1 by phosphorylation at Ser 65 which in
turn interacts with ubiquitin that is also phosphorylated at Ser 65. This
process is important for removing the damaged mitochondria by mitophagy
(selective autophagy) by mediating activation and translocation of PARK2. Recombinant human PINK1 effectively
phosphorylates recombinant Parkin, mono-Ubiquitin, and poly-Ubiquitin chains.
It specifically phosphorylates both Parkin and Ubiquitin at serine 65. This
recombinant protein contains an MBP tag.
Purity: > 90% by SDS-PAGE
Molecular Weight: 106 kDa by SDS-PAGE
Physical State: Liquid
Storage: -80°C. Avoid repeated freeze/thaw cycles
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