JAMM

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AMSH

Catalog Number
DB301
Molecular Weight
49kDa
Family
JAMM
Physical State
Liquid
Purity
>90%
Alternate Name(s)
STAMBP, MGC126516, MGC126518, STAM-binding protein
Fusion Tag
His6
Source
Human Recombinant
Package Size
25ug
Active
Yes

Product Information

Price

$345.00 USD

Storage/Stability
References

Documentation

Datasheet

Product Description

AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR)1. Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR1. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM2.

Activity: This enzyme cleaves K63-linked ubiquitin chains in vitro.

 

Storage/Stability

Store at -80°C, avoiding repeated freeze-thaw cycles.

 

References

1: McCullough, J., M.J. Clague, and S. Urbe, AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol, 2004. 166(4): p. 487-92.

2: McCullough, J., et al., Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2): p. 160-5.