Mammalian deSUMOylases (SENPs) are cysteine proteases that process pro-small ubiquitin-related modifier (SUMOs) and cleave isopeptide bonds between SUMO and proteins. The Saccharomyces cerevisiae SUMO ortholog Smt3 is cleaved by the SENP homologs Ulp1 and Ulp2.

For Ulp1core, please see SUMO Protease 1.

For SENP2core, please see SUMO Protease 2.